vursusa.blogg.se - Antidote of benzodiazepines

These are compounds containing an imidazole ring and a 1,4-benzodiazepine ring system, both sharing one nitrogen atom.

Miscellaneous Central Nervous System AgentsĬhemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as imidazobenzodiazepines.Compounds used in a research, industrial, or household setting.

1 L/hr/kg Ībacavir may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īceclofenac may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īcemetacin may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īcetaminophen may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īcetazolamide may increase the excretion rate of Flumazenil which could result in a lower serum level and potentially a reduction in efficacy.Īcetylsalicylic acid may decrease the excretion rate of Flumazenil which could result in a higher serum level.įlumazenil may decrease the excretion rate of Aclidinium which could result in a higher serum level.įlumazenil may decrease the excretion rate of Acrivastine which could result in a higher serum level.Īcyclovir may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īdefovir dipivoxil may decrease the excretion rate of Flumazenil which could result in a higher serum level.Īccess now International/Other Brands Anexate (Hoffmann-La Roche) / Lanexat / Mazicon Brand Name Prescription Products NameĬategories ATC Codes V03AB25 - Flumazenil.

Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes). Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Elimination of radiolabeled drug is essentially complete within 72 hours, with 90% to 95% of the radioactivity appearing in urine and 5% to 10% in the feces. Route of eliminationįlumazenil is completely (99%) metabolized. The major metabolites of flumazenil identified in urine are the de-ethylated free acid and its glucuronide conjugate. Flumazenil is completely (99%) metabolized. Protein binding is reduced in patients with hepatic cirrhosis. Protein binding is approximately 50%, mostly (66%) to albumin.